5. Deon Jackson, RB, Indianapolis Colts at New England Patriots
With no Jonathan Taylor (ankle) and rookie QB Sam Ehlinger under center, the backfield is not looking to thrill anyone with production this week. Jackson will get the start, and will give pause to those savvy owners who stocked up on the Colts’ backfield depth. Should you start him? Only if you have no better options.
The Patriots are a difficult team to run on. They’ve allowed huge games to Aaron Jones and A.J. Dillon, yardage wise, back in Week 4. But neither back scored. In fact, the only backs to have scored against the Patriots were Khalil Herbert and David Montgomery. With a rookie QB at the helm, Jackson is going to have the volume to justify a start, but it will be close for him to eclipse 100 total yards.